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Quantification of the amount of VCAM-1 staining was performed with ImageJ software and plotted at the positive stain over the total tissue area

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It was later used as a weight loss drug and eventually FDA-approved for weight loss in 2021

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NNMT is upregulated in the white adipose tissue of obese animals and humans, and its activity is mechanistically linked to depleted cellular NAD+ and SAM pools

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